QSAR Studies on Andrographolide Derivatives as α-Glucosidase Inhibitors
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چکیده
منابع مشابه
QSAR Studies on Andrographolide Derivatives as α-Glucosidase Inhibitors
Andrographolide derivatives were shown to inhibit alpha-glucosidase. To investigate the relationship between activities and structures of andrographolide derivatives, a training set was chosen from 25 andrographolide derivatives by the principal component analysis (PCA) method, and a quantitative structure-activity relationship (QSAR) was established by 2D and 3D QSAR methods. The cross-validat...
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A linear quantitative structure-activity relationship (QSAR) model is presented for modeling and predicting the αglucosidase inhibitory activity. The model was produced by using the multiple linear regression (MLR) technique on a twenty one compound database that consists of newly discovered 2,4-thiazolidinediones. The major conclusion of this study is that molecular weight, wiener index, andre...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2010
ISSN: 1422-0067
DOI: 10.3390/ijms11030880